Towards a cross-correlation approach to strong-field dynamics in Black Hole spacetimes

The qualitative and quantitative understanding of near-horizon gravitational dynamics in the strong-field regime represents a challenge both at a fundamental level and in astrophysical applications. Recent advances in numerical relativity and in the geometric characterization of black hole horizons open new conceptual and technical avenues into the problem. We discuss here a research methodology in which spacetime dynamics is probed through the cross-correlation of geometric quantities constructed on the black hole horizon and on null infinity. These two hypersurfaces respond to evolving gravitational fields in the bulk, providing canonical "test screens" in a "scattering"-like perspective onto spacetime dynamics. More specifically, we adopt a 3+1 Initial Value Problem approach to the construction of generic spacetimes and discuss the role and properties of dynamical trapping horizons as canonical inner "screens" in this context. We apply these ideas and techniques to the study of the recoil dynamics in post-merger binary black holes, an important issue in supermassive galactic black hole mergers.Comment: 16 pages, 5 figures, contribution to the proceedings volume of the Spanish Relativity Meeting ERE2011: "Towards new paradigms", Madrid, Spain, 29 Aug-2 Sep 201

Fasciolose.

bitstream/item/59412/1/Midia-Fasciolose.pd

Additivity of elementary maps on gamma rings

Let M and M' be Gamma rings, respectively. We study the additivity of surjective elementary maps of M ⨉ M'. We prove that if M contains a non-trivial γ-idempotent satisfying some conditions, then they are additive.peerReviewe

Cultivo de fruteiras em sistemas agroflorestais.

O que são Sistemas Agroflorestais (SAF). O novo conceito de sistemas agroflorestais. Interações entre componentes em sistemas agroflorestais. Critérios para escolha de espécies frutíferas para comporem sistemas agroflorestais. Diagnóstico de problemas de uso da terra e o desenho tecnologias agroflorestais

Use of Estimating Equations for Dosing Antimicrobials in Patients with Acute Kidney Injury Not Receiving Renal Replacement Therapy.

Acute kidney injury (AKI) can potentially lead to the accumulation of antimicrobial drugs with significant renal clearance. Drug dosing adjustments are commonly made using the Cockcroft-Gault estimate of creatinine clearance (CLcr). The Modified Jelliffe equation is significantly better at estimating kidney function than the Cockcroft-Gault equation in the setting of AKI. The objective of this study is to assess the degree of antimicrobial dosing discordance using different glomerular filtration rate (GFR) estimating equations. This is a retrospective evaluation of antimicrobial dosing using different estimating equations for kidney function in AKI and comparison to Cockcroft-Gault estimation as a reference. Considering the Cockcroft-Gault estimate as the criterion standard, antimicrobials were appropriately adjusted at most 80.7% of the time. On average, kidney function changed by 30 mL/min over the course of an AKI episode. The median clearance at the peak serum creatinine was 27.4 (9.3⁻66.3) mL/min for Cockcroft Gault, 19.8 (9.8⁻47.0) mL/min/1.73 m² for MDRD and 20.5 (4.9⁻49.6) mL/min for the Modified Jelliffe equations. The discordance rate for antimicrobial dosing ranged from a minimum of 8.6% to a maximum of 16.4%. In the event of discordance, the dose administered was supra-therapeutic 100% of the time using the Modified Jelliffe equation. Use of estimating equations other than the Cockcroft Gault equation may significantly alter dosing of antimicrobials in AKI

Phenotype standardization for drug-induced kidney disease.

Drug-induced kidney disease is a frequent cause of renal dysfunction; however, there are no standards to identify and characterize the spectrum of these disorders. We convened a panel of international, adult and pediatric, nephrologists and pharmacists to develop standardized phenotypes for drug-induced kidney disease as part of the phenotype standardization project initiated by the International Serious Adverse Events Consortium. We propose four phenotypes of drug-induced kidney disease based on clinical presentation: acute kidney injury, glomerular, tubular, and nephrolithiasis, along with the primary and secondary clinical criteria to support the phenotype definition, and a time course based on the KDIGO/AKIN definitions of acute kidney injury, acute kidney disease, and chronic kidney disease. Establishing causality in drug-induced kidney disease is challenging and requires knowledge of the biological plausibility for the specific drug, mechanism of injury, time course, and assessment of competing risk factors. These phenotypes provide a consistent framework for clinicians, investigators, industry, and regulatory agencies to evaluate drug nephrotoxicity across various settings. We believe that this is the first step to recognizing drug-induced kidney disease and developing strategies to prevent and manage this condition